James David Ebert studied the developmental processes of chicks and of viruses in the US during the twentieth century. He also helped build and grow many research institutions, such as the Department of Embryology in the Carnegie Institution of Washington in Baltimore, Maryland and the Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts. When few biologists studied the biochemistry of embryos, Ebert built programs and courses around the foci of biochemistry and genetics, especially with regards to embryology. He eventually directed the MBL's Embryology Course, and later, the MBL itself.
Ebert was born on 11 December 1921 in the town of Bentleyville, Pennsylvania. He attended public schools while growing up and then graduated from Washington and Jefferson College in Washington, Pennsylvania in 1942. Not long after graduation he joined the United States Navy and eventually became a lieutenant. Ebert was stationed on a destroyer in the Pacific Ocean that was attacked by a kamikaze pilot. The destroyer sank and Ebert spent twenty-four hours in the ocean until being rescued. Afterwards, as a biologist, Ebert befriended and trained several Japanese developmental biologists.
In 1946 Ebert began working towards his PhD in developmental biology under the instruction of Benjamin Willier at the Johns Hopkins University in Baltimore, Maryland. In the same year he married Alma Goodwin, who was a Women Accepted for Volunteer Emergency during the war. Ebert received his PhD in 1950 and immediately became a member of the faculty at the Massachusetts Institute of Technology (MIT) in Cambridge, Massachusetts. After one year at MIT, Ebert moved to Indiana University in Bloomington, Indiana. Ebert became an associate professor of zoology by 1955, and he had started a program of experimental embryology. He studied chick embryos and the processes by which the protein make-up of the embryos changed throughout development.
Six years after receiving his PhD, Ebert became the director of the Carnegie Institution of Washington's Department of Embryology, in Baltimore, Maryland. Prior to Ebert's term as director, the department had had three other directors. The Institution's president, Caryl Haskins, had contemplated closing the department and starting something new. However, with some persuasion from Willier, Haskins spoke with Ebert and decided to give him the opportunity to run the department. Ebert and Haskins agreed that the department needed to focus on the study of genes and their regulation as well as the ways cells influence one another. Haskins said that Ebert's youth and enthusiastic personality made Haskins believe that Ebert would provide a fresh perspective to the department.
Ebert argued that it was his job to recognize and to recruit new talent and then support them in their work. He stressed the use of biochemistry and genetics, which in the 1960s blended together to form molecular biology. During this time, Ebert started to study the relationship between muscle cell differentiation and the propensity to infection in the Rous sarcoma virus.
While still director of the Carnegie embryology department, in 1970 Ebert also became the president and nonresident director of the Marine Biological Laboratory (MBL) at Woods Hole. At the MBL he researched, with Keiko Ozato, the response of murine lymphocytes to mitogens.
In 1977 Ebert ended his term at the Carnegie Department of Embryology, but he remained the director of the MBL. From 1978 until 1987, Ebert lived in Washington, D.C., and he was the president of the whole Carnegie Institution of Washington. As the institution's president, he made the decision to help build a large optical telescope in Chile at Las Campanas Observatory, and he worked towards the creation of a common campus for both Carnegie departments in Washington.
Ebert remained involved with scientific institutions for the rest of his life. When leaving one institution, he found another one to join. He retired from the Carnegie Institution in 1987 and became the president of the Chesapeake Bay Institute at the Johns Hopkins University, where he was a professor of biology for six years. Ebert was elected to many societies including the National Academy of Sciences, the American Philosophical Society, the American Academy of Arts and Sciences, and the Institute of Medicine. He was the vice president of the National Academy of Sciences from 1981 through 1993 and he also chaired its Government-University-Industry Research Roundtable from 1987 through 1993. His colleagues elected him as president of the Society for the Study of Development and Growth, the American Institute of Biological Sciences, and the American Society of Zoologists.
In retirement, Ebert and his wife Alma spent half of each year in Woods Hole and at the MBL. Ebert and Alma died on 22 May 2001 in an automobile accident while en route to Woods Hole.
- DeHaan, Robert L., and James D. Ebert. "Morphogenesis." Annual Review of Physiology 26 (1964): 15–46.
- Ebert, James D. "An analysis of the effects of anti-organ sera on the development, in vitro, of the early chick blastoderm." Journal of Experimental Zoology 115 (1950): 351–77.
- Ebert, James D. "An analysis of the synthesis and distribution of the contractile protein, myosin, in the development of the heart." Proceedings of the National Academy of Sciences 39 (1953): 333–44.
- Ebert, James D. "The effects of chorioallantoic transplants of adult chicken tissues on homologous tissues of the host chick embryo." Proceedings of the National Academy of Sciences 40 (1954): 337–47.
- Ebert, James D. "The formation of muscle and muscle-like elements in the chorioallantoic membrane following inoculation of a mixture of cardiac microsomes and Rous sarcoma virus." Journal of Experimental Zoology 142 (1959): 587–621.
- Ebert, James D., and Ian M. Sussex. Interacting Systems in Development. New York: Holt, Rinehart and Winston, 1970.
- Ebert, James D., and Fred H. Wilt. "Animal Viruses and Embryos." The Quarterly Review of Biology 35 (1960): 261–312.
- Obituaries. "Jim and Alma Ebert." Marine Biological Laboratory. http://www.mbl.edu/news/obit/obit_ebert.html (Accessed December 8, 2007).
- Ozato, Keiko, William H. Adler, and James D. Ebert. "Synergism of bacterial lipopolysaccharides and concanavalin A in the activation of thymic lymphocytes." Cellular Immunology 17 (1975): 532–41.
- Singer, Maxine. "James David Ebert." Proceedings of the American Philosophical Society 148 (2004): 124–27.
James David Ebert studied the developmental processes of chicks and of viruses in the US during the twentieth century. He also helped build and grow many research institutions, such as the Department of Embryology in the Carnegie Institution of Washington in Baltimore, Maryland and the Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts. When few biologists studied the biochemistry of embryos, Ebert built programs and courses around the foci of biochemistry and genetics, especially with regards to embryology.Created: 2008-09-12
The Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, began in 1888 to offer opportunities for instruction and research in biological topics. For the first few years, this meant that individual investigators had a small lab space upstairs in the one wooden building on campus where students heard their lectures and did their research in a common area downstairs. The lectures for those first years offered an overview of general biology with a focus on zoology, and they were intended for teachers and graduate students interested in acquiring the background for teaching about and/or actually doing laboratory work. As the lab quickly grew, it added sets of lectures that made up courses in zoology, then botany, then physiology, and in 1893 what became the first Embryology Course.
The 1890s were a lively time in embryology, with new techniques and discoveries related to the roles of cells in development, and a growing excitement about the way that experimental embryological manipulations could reveal processes that otherwise remain inside the usually opaque embryo. The MBL recognized the importance of this work and began their course in embryology, which was offered as an elementary course in vertebrate embryology. This was designed for those who had already had the general course, and it had the appeal of offering something more advanced that would bring students back for an additional year. The goal that first year was to allow students to discover the details of development, and to learn the methods for doing the work. The six-week course was directed by Charles Otis Whitman, who was the MBL director, and his student and protégé Frank Rattray Lillie, who became Whitman’s Assistant Director and then his successor as Director both at the MBL and also at the Biology Department at the University of Chicago.
Students were expected to bring their own equipment, including a compound microscope, a dissecting microscope (and it was specified that the Paul Meyer pattern made by Zeiss was the best of the kind), a camera lucida , microtome, and other standard embryological equipment to make up a “complete outfit.” Each student was given a supply of fish eggs and expected to follow the stages of development starting with fertilization. The camera lucida was to facilitate drawing, which was an important part of embryological work until relatively recently. The students all learned the most up-to-date techniques for observing, preserving, embedding, fixing, staining, and then drawing, reconstructing, and modeling embryological processes. The course cost fifty dollars for a number of years and was limited to a dozen students.
For the second year, students were required to have not just a general biology course but also an anatomy course as a pre-requisite. The course continued until 1901, when the lab had grown enough that the course expanded its staff and added zoology as a pre-requisite. The goal of the course was not just to teach the basics of embryology but also to prepare students to take up independent investigations of their own. In addition, the course announcements emphasized the value of studying such a subject at the MBL. Here it was not necessary to rely on preserved developmental stages fixed to slides, but it was possible also to study the living material available during a summer at the seashore. The course continued, with new directors and instructors and with students going on to their own research and sometimes returning as instructors themselves.
Only in 1921 did the course begin to cost seventy-five dollars. Hubert Goodrich became director in 1922 and remained so until 1942. This was an important time for embryology, and the course clearly offered the basics in experimental techniques and introduction to modern theory. It probably served as a very valuable introduction for many young scientists, who encountered living material, interacted with established researchers, and learned how to use equipment and techniques not just to see what others had reported before but also how to ask new questions and prod the embryos to yield answers.
1942 brought a continuation of the basic approach but also a new director. Viktor Hamburger had served as an instructor (view PDF [10.1 MB] of original Hamburger lecture notes) since 1937, shortly after he had taken his experience in Hans Spemann’s lab in Germany to the University of Chicago. There, Lillie undoubtedly lured him to the MBL for the summer and put him to work. Hamburger directed the Embryology Course from 1942 through 1945, when long-time instructor, Donald Costello from the University of North Carolina, took over through 1950. Where Hamburger looked at neuroembryology in his own work and emphasized patterns of development and causes of differentiation, Costello was especially interested in comparative invertebrate embryology. No doubt their approaches worked together well, and the course retained its flavor of lab research drawing on the natural history of the marine offerings.
In the 1950s S. Meryl Rose from the University of Illinois and then Mac V. Edds from Brown University directed the course. This is a period when such notables as John Tyler Bonner of Princeton University, with his enthusiasm for slime molds and problems of morphogenesis, John P. Trinkaus (known as Trink), Clifford Grobstein from the National Cancer Center, Philip Grant from Johns Hopkins University, John W. Saunders from Marquette University, and others brought new perspectives to the traditional course. Throughout this period and dating back to the 1940s, they listed a set of books that students should have, and the list remained surprisingly constant in ways that would be unlikely in this rapidly changing field today.
In 1962 James Ebert at the Carnegie Institution of Washington became director and things changed. The course description shifted for the next year, and the course fee rose to $300—$150 for the series of lectures plus $150 for those who wished to stay for an additional period of individual investigation. The course was becoming less introductory and more designed for would-be researchers such as graduate students and post-doctoral fellows who wanted to learn advanced techniques and to hear about theories and problems in development. The content remained, with additions of Ebert’s specialty work in organogenesis, but Ebert’s five year run as course director made the course at least look more professional in its focus on modern technical topics. This move to professionalism was reinforced by NIH training grants that supported the Embryology and sometimes other courses in the late 1960s and beyond.
In 1971 the course fees rose to $400 + $400, and the announcement made clear that the course was targeted to graduate students and post-doctoral fellows, and to advanced undergraduates seriously interested in pursuing research in this field. Also in 1971, Eric Davidson from Cal Tech served as an instructor. In 1972 he became course director and served in that role through 1974, then again from 1988 through 1996, making him the longest-running course director and giving him the opportunity for the greatest impact on the history of the course. He took great advantage of the opportunity to revise and update the course. In fact, Davidson brought the first major changes in the course which was now “centered around one particular conceptual area of developmental biology.” And the emphasis clearly shifted from instruction and introduction to research to a higher level of expected training and investment in research on the part of the participants.
The focus for 1972 was cytoplasmic localization phenomena, for 1973 the synthesis, storage, and utilization of developmental genetic information during oogenesis in vertebrates and invertebrates, and in 1974 “Sequence Organization in the animal genome and transcription-level gene regulation.” This was a significant shift, and arguably Ebert and Davidson in their different ways had done the most to move the traditional popular course into the professional and molecular era of the late twentieth century.
David Epel from the University of California at San Diego brought an emphasis on cells and cell-cell communication with “Cell Interactions, Cell Membranes, and Cell Surfaces in Development” (1975). Then Tom Humphreys from the University of Hawaii joined Epel in offering “Developmental Regulation of Gene Expression” (1976), “Extracellular Signals in Cell Growth and Differentiation” (1977), and “Localization, Pattern Formation, and Morphogenesis” (1978 and 1979). Rudolf Raff from Indiana University directed “The Control of Events in Early Embryology Development” (1980), “Gene Control and the Events of Early Embryonic Development” (1981), and “Cytoplasmic Localization, Determination, and Gene Control in Development” (1982). These years brought a much expanded list of instructors and lecturers, as the field became more complex and it was important to bring together speakers across the wide range of new ideas and techniques.
Then in 1984, under the direction of William Jeffery from the University of Texas at Austin and Bruce Brandhorst from McGill University, the course reverted to the simpler title of “Embryology: A Modern Course in Developmental Biology.” From 1989 through 1996 the title was “Embryology: Cell Differentiation and Gene Expression in Early Development” and from 1997 to present, it has been “Embryology: Concepts and Techniques in Modern Developmental Biology.”
Discussions by the Education Committee and course directors at various points show that the MBL considered whether to change the name to reflect more current thinking, namely with an emphasis on developmental biology and an emphasis on molecular genetics rather than the traditional embryology. They decided to stick with the traditional course that is now more than one hundred and fifteen years old and instead added other January short courses focused on developmental and molecular techniques. Of course the Embryology course, taught in traditional labs, includes a considerable dose of modern molecular work. And students in recent years admit that they no longer go out to muck about and collect specimens themselves, nor do they have any idea where to look in most cases. Yet there is a tie to tradition, to the observations and collections of the past century, and course instructors will send their students to the MBL Rare Books Room to discover something of the history and context of the work that is now so different from and yet so grounded in the traditions of its predecessors.
View a timeline of the directors and instructors here.
- Marine Biological Laboratory Annual Announcements: MBL-WHOI Library Special Collections.
- Marine Biological Laboratory Annual Reports: available in the MBL The Biological Bulletin Vols. 17 and 21–105 at http://www.archive.org/details/biologicalbullet01mari and beginning with 2004 at http://www.mbl.edu/governance/gov_annual_report.html.
The Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, began in 1888 to offer opportunities for instruction and research in biological topics. For the first few years, this meant that individual investigators had a small lab space upstairs in the one wooden building on campus where students heard their lectures and did their research in a common area downstairs.Created: 2007-10-24
The Marine Biological Laboratory (MBL) was founded in 1888 in Woods Hole, Massachusetts. Woods Hole was already the site for the government’s US Fish Commission Laboratory directed by Spencer Fullerton Baird, and it seemed like the obvious place to add an independent research laboratory that would draw individual scientific investigators along with students and instructors for courses. From the beginning, the lab had the dual mission of teaching and research, and from the beginning leading biologists have found their way to this small village on the “heel” tip of Cape Cod.
Supported by trustees who were largely in the Boston area, the lab opened its doors that first year with one small wooden building and great enthusiasm. Advertising was largely word of mouth since the building was still being constructed and the supplies had not yet arrived up to the last minute. Nonetheless, eight students and seven investigators made up the pioneer group in a six week session with a budget of just over $10,000 to build and equip the new laboratory building. With a focus on marine life, Balfour H. Van Vleck served as first instructor for a general zoology course.
The second year brought considerable expansion to six instructors and the addition of botany. After that, the lab was on its way to becoming an international presence in marine biology and eventually in certain defined areas of biology generally. From the beginning, embryology was one of the primary focus areas of the lab, and it has remained so throughout the MBL’s 120-plus years. The leadership of the laboratory had a strong embryological interest from the beginning, as did the individual investigators and trustees. Especially when the work was experimental, the emphasis was sometimes labeled “physiology” instead of “experimental embryology” to get at fundamental processes of development.
Charles Otis Whitman served as first director of the lab. He had directed the small private Allis Lake Laboratory near Milwaukee, Wisconsin, then directed the biology program at Clark University, and then the biology program at the University of Chicago. Whitman was an able administrator who inspired people intellectually, and he somehow managed to make things work even when money was short. This is probably due in large part to the talents of Frank Rattray Lillie, who followed Whitman at Chicago and at the MBL where he became Assistant Director and then second Director. Where Whitman left financial matters to hope, saying things like “well, what is money for?,” Lillie was an astute manager with support from his wealthy brother-in-law Charles Crane and other individuals and foundations. Whitman and Lillie made a fine team, and they attracted a board of trustees that included top research biologists and also loyal donors. This has remained true, as the MBL has developed a Corporation of research scientists who pay a membership to be part of the group, plus installed a governing Board of Trustees to oversee operations. Despite some challenging times and some tempting take-over offers, the lab has always remained independent; research and instruction both have increasingly come to rely on federal grants and private foundations but the lab has resisted various attempts to make it an arm of a university, the government, or other organizations.
In 1890 the lab started a series of evening lectures that became known as the Friday Evening Lectures. The goals of offering these lectures and advertising them widely to the public were twofold: first to take science to the larger public and increase interest in science, and second to bring specialists together to learn from each other. Lecturers were instructed to make their talks accessible to beginners as well as of value to senior researchers. These were not intended to be courses, but rather to supplement the systematic organized instruction of the courses. For the years 1890–1899, the lectures were published as the Biological Lectures Delivered at the Marine Biological Laboratory in Woods Holl.
Courses included zoology, of course, and botany starting in the second year. In addition, Jacques Loeb added physiology as a focus. By 1893 the lab announced instruction in zoology, botany, embryology, physiology, and microscopical technique. In particular, Whitman was directing a course of lectures in embryology, working with Lillie. The Embryology Course has remained a core part of the MBL instructional offerings since 1893, with additional specialized training programs at different times with different emphases.
From the beginning, individuals or institutions could rent lab space and carry out investigations. Since embryological research drew heavily on comparative studies of marine development, it made sense for universities to send their embryologists to the seashore to do work. As Philip Pauly noted, the combination of doing one’s research while summering at the seashore was a tremendously attractive option. The MBL has always been a place for the world’s top embryologists to gather in the labs, in lectures, on sailing picnics, and with their families at the beaches. Annual Reports show the range of work done at the MBL, and since 1897 the publication of the Biological Bulletin has added an outlet for research carried out by MBL researchers and others.
For the early decades of the lab, embryological work centered on descriptive and comparative studies, especially cell lineage work that reported the details of each cell division for as long as it could be followed in each organism. Different researchers took up different organisms and compared their results, developing concepts of determinative and regulatory development depending on how much the cell divisions could respond to changing environmental conditions. Edmund Beecher Wilson placed cells at the center of developmental research, with his masterful The Cell in Development and Inheritance (1896; second edition 1900; much revised third edition 1925). Then the early twentieth-century brought experimental embryology, and by the 1950s and 1960s embryology embraced genetics and became known as developmental biology. Leaders such as James Ebert and Eric Davidson led the lab and also the Embryology Course in the direction of studying differentiation through processes like organogenesis or genetic regulation of development, for example.
While other places often gave up the embryos, the MBL has retained an interest not just in the cells and molecules but also in the developing organisms, which exist in specific environments and depend on complex systems of interacting cell signals and environmental cues. The Embryology Course and the investigation carried out in labs has changed over the 120-plus years at the MBL, but the MBL has played an important role in securing the central place of embryos and the value of comparative study of developmental processes. Perhaps being near the organisms and being able to have them delivered directly from the collectors in the Supply Department makes them more real and the interactions of the parts more salient.
Complex systems, modeling, molecules, and physiological systems all join together in the study of marine and related material at the Marine Biological Laboratory. Researchers have gone out to collect their specimens and have kept them alive in the on-demand seawater running through designated pipes. They have studied normal development, pathologies, and experimental conditions. Generation, regeneration, and new generation are on the research agenda. As the Annual Reports show starting with the very first years, the MBL has been a place for leading investigation and instruction in several areas including embryology, neurobiology, and physiology. Over the years, this has placed the MBL in a solid position to develop such diverse promising areas of research as molecular genetics, neuroembryology, and regenerative medicine.
View a timeline of the MBL here.
- Lillie, Frank R. The Woods Hole Marine Biological Laboratory. Chicago: the University of Chicago Press, 1944. Reprinted as a Supplement to The Biological Bulletin Vol. 174 (1988) available at http://www.biodiversitylibrary.org/item/17426.
- Maienschein, Jane. 100 Years Exploring Life, 1888–1988. Boston: Jones and Bartlett Publishers, 1989.
- Marine Biological Laboratory Annual Reports: available in the MBL Biological Bulletin Vols. 17 and 21–105 at ,http://www.archive.org/details/biologicalbullet01mari and beginning with 2004 at http://www.mbl.edu/governance/gov_annual_report.html.
- Marine Biological Laboratory. Symposium Supplement to The Biological Bulletin Vol. 168 (1985): 1–204.
- Pauly, Philip. “Summer Resort and Scientific Discipline: Woods Hole and the Structure of American Biology, 1882–1925.” In The American Development of Biology, eds. Ronald Rainger, Keith R. Benson, and Jane Maienschein, 121–150., Philadelphia: University of Pennsylvania Press, 1988.
The Marine Biological Laboratory (MBL) was founded in 1888 in Woods Hole, Massachusetts. Woods Hole was already the site for the government 's US Fish Commission Laboratory directed by Spencer Fullerton Baird, and it seemed like the obvious place to add an independent research laboratory that would draw individual scientific investigators along with students and instructors for courses.Created: 2008-10-24